2008;71(9):1846-1854. Zahrani SH, Amjady MA, Mojab F, and et al. © 2005 - 2019 WebMD LLC. Because fennel is not approved by the FDA for any condition, there is no official dose. Taking fennel along with tamoxifen might decrease the effectiveness of tamoxifen (Nolvadex). Fennel is a spice and a medicinal plant with a long tradition. View abstract. Both fennel and its seeds are packed with nutrients. Side Effects & Safety When taken by mouth: Caraway is LIKELY SAFE for most people in food amounts. Shah, A. H., Qureshi, S., and Ageel, A. M. Toxicity studies in mice of ethanol extracts of Foeniculum vulgare fruit and Ruta chalepensis aerial parts. Additional, preferably larger human studies are needed to explore the potential benefits of fennel on skin health. However the side effects also include reactions in the respiratory system. Bronchial asthma due to ingestion of fennel and fennel seed. Your email address will not be published. Having sad that, without much ado, let's learn about fennel seeds benefits. Altern.Ther.Health Med. This herb is an abundant source of antioxidants such as caffeoylquinic acid, quercetin, and other phenolic and flavonoid compounds [32, 33]. The opinions expressed in this section are solely those of fennel users, who may or may not have medical or scientific training. Gilligan NP. It blocked acetylcholinesterase, an enzyme that breaks down acetylcholine, in mice . Electronic Code of Federal Regulations. Cuzzolin L, Zaffani S, and Benoni G. Safety implications regarding use of phytomedicines. Eating fennel seeds helps in developing appetite especially in the first trimester and helps control morning sickness by reducing gas and heartburn. Pediatr.Emerg.Care 2005;21(8):536-538. Ann.N.Y Acad.Sci. Pediatr Med Chir 1995;17(6):525-530. Wei Sheng Yan.Jiu. Where did you or where do you plan to purchase this product? Uncontrolled Blood Sugar: How Dangerous Is It? Increasing sexual desire in healthy people. J Gastrointestin Liver Dis. 2007;36(6):828-835. A randomized double-blind placebo-controlled trial of a standardized extract of Matricariae recutita, Foeniculum vulgare and Melissa officinalis (ColiMil) in the treatment of breastfed colicky infants. However, larger, well-designed trials are needed to establish that fennel is beneficial for this condition. Clin Exp Hypertens. Three weeks of fennel supplementation increased the activity of important antioxidant enzymes superoxide dismutase (SOD) and catalase in rats . 1. This means it can act similarly to estrogen hormone. dulce (sweet fennel), Anthemis nobilis (Roman chamomile) and Mentha x piperita (peppermint). 1. Effect of Foeniculum vulgare (fennel) vaginal cream on vaginal atrophy in postmenopausal women: a double-blind randomized placebo-controlled trial. 5-24-2006;105(3):449-455. This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. Javidnia, K., Dastgheib, L., Mohammadi, Samani S., and Nasiri, A. Antihirsutism activity of Fennel (fruits of Foeniculum vulgare) extract. Infant Colic-What works: A Systematic Review of Interventions for Breast-fed Infants. It was also safe in infants, although in such cases it was usually only used for relatively short periods of time . Fennel extract has shown significant anti-inflammatory effects in rats and mice. J Ethnopharmacol. Fennel is safe when consumed moderately, yet sometimes it can have side effects. If you take birth control pills along with fennel, use an additional form of birth control such as a condom. Note that each number in parentheses [1, 2, 3, etc.] This site uses Akismet to reduce spam. View abstract. She spent 4 years reviewing the scientific literature on supplements, lab tests and other areas of health sciences. View abstract. In most clinical studies, fennel capsules containing 100 mg of active ingredients were given 2 or 3 times per day. 2020;17(1):68-78. Tognolini, M., Ballabeni, V., Bertoni, S., Bruni, R., Impicciatore, M., and Barocelli, E. Protective effect of Foeniculum vulgare essential oil and anethole in an experimental model of thrombosis. View abstract. As a kid, he suffered from inflammation, brain fog, fatigue, digestive problems, anxiety, depression, and other issues that were poorly understood in both conventional and alternative medicine. This increases acetylcholine and improves the creation of memories. The oil may cause hallucinations and seizures. All of our content is written by scientists and people with a strong science background. Therefore, taking this herb may enhance the effects of these drugs, potentially causing undesired side effects [60, 61]. 1981;20:51-4. 5-19-2004;52(10):2887-2889. Birth control pills (Contraceptive drugs) interacts with FENNEL. This herb suppressed inflammation in mice with lung injury, by decreasing the production of inflammatory cytokines IL-6 and TNF-alpha and the inflammatory agents MMP9 and nitric oxide (NO) . Research indicates that pure estragole is deactivated by many other substances contained in these plants . It may work by decreasing inflammatory mediators, which can worsen the sensation of pain [43, 5]. 2010;10:17. J Ethnopharmacol. 2003;10(6-7):455-458. 12-12-2007;55(25):10162-10167. Some have also used it while breastfeeding. Tognolini, M., Barocelli, E., Ballabeni, V., Bruni, R., Bianchi, A., Chiavarini, M., and Impicciatore, M. Comparative screening of plant essential oils: phenylpropanoid moiety as basic core for antiplatelet activity. Fennel has been traditionally used by breastfeeding mothers to increase breast milk production . 2016 Jun;25(2):151-7. Kim, D. H., Kim, S. I., Chang, K. S., and Ahn, Y. J. Repellent activity of constituents identified in Foeniculum vulgare fruit against Aedes aegypti (Diptera: Culicidae). Menopause. Large amounts of fennel might have some of the same effects as estrogen. Historically, fennel has been used as a remedy for many infectious disorders . From regulating blood pressure to water retention, fennel seeds pack a bevy of nutrients that make it a must have in your kitchen. 2003;9(4):58-61. In a triple-blind, placebo-controlled trial of 90 women, fennel effectively reduced menopausal symptoms without serious side effects . Premature breast development in girls has been reported with the use of fennel. Fennel, particularly its ingredient anethole, decreased pain in animals without causing sedation. Fennel essential oil reduced blood sugar levels in rats with diabetes by nearly 50%. Indian J Pharmacol 1999;31(2):159. There are a couple of cases where fennel induced seizures in epileptic patients [58, 59]. May Interact With Drugs. However, these effects have only been reported in rodents so far, so it’s an open question whether this herb will have as dramatic an effect on cholesterol in human users. Chem.Res Toxicol. J Pediatr 1993;122(4):650-652. Thinning of vaginal tissue (vaginal atrophy). An infection of the intestines that causes diarrhea (cholera). Here are some 9 great fennel seed benefits: 1. Part 182 -- Substances Generally Recognized As Safe. However, there are no studies that directly tested the effects of fennel on milk production. Save my name, email, and website in this browser for the next time I comment. However, frequent use may cause some side effects due to its estrogen-like activity. Fennel seeds help in reducing weight by decreasing the cravings and hunger. 2006;7(9):556-561. In the midst of the Coronavirus pandemic, we’ve got to do everything we can to keep our bodies as healthy as possible. Aggarwal, B. Menstrual cramps (dysmenorrhea). ... Side effects of fennel. View abstract. Platel K and Srinivasan K. A Study of the digestive stimulant action of select spices in experimental rats. No clinical evidence supports the use of fennel for any of the conditions listed in this section. However, this study is small and insufficient to draw any conclusions. "Natural" relief of pregnancy-related symptoms and neonatal outcomes: above all do no harm. Learn how your comment data is processed. In a DB-RCT of 60 post-menopausal women, fennel showed borderline significant improvement in treating anxiety and depression . Fennel side effects. (check all that apply), What factors are most important to you? View abstract. Gutierrez, J., Rodriguez, G., Barry-Ryan, C., and Bourke, P. Efficacy of plant essential oils against foodborne pathogens and spoilage bacteria associated with ready-to-eat vegetables: antimicrobial and sensory screening. Another study noticed the increase in HDL-cholesterol in rats . Falahat F, Ayatiafin S, Jarahi L, et al. J Food Prot. Early research shows that giving fennel to infants with colic might reduce crying by a small amount. Antioxidant Properties. In a study with 121 people who had Irritable Bowel Syndrome (IBS), a mixture of fennel and curcumin essential oils decreased abdominal pain and improved quality of life . As a natural product, some argue that the side effects associated with fennel seed are limited. Zeller, A., Horst, K., and Rychlik, M. Study of the metabolism of estragole in humans consuming fennel tea. Picon, P. D., Picon, R. V., Costa, A. F., Sander, G. B., Amaral, K. M., Aboy, A. L., and Henriques, A. T. Randomized clinical trial of a phytotherapic compound containing Pimpinella anisum, Foeniculum vulgare, Sambucus nigra, and Cassia augustifolia for chronic constipation. Highly nutritious. It contains prolactin and … Some types of cancer are affected by hormones in the body. It not … When the skin comes in contact with these compounds, ... 2. J Ethnopharmacol 2001;76:299-304.. View abstract. In theory, dopamine blocks prolactin, a hormone that stimulates breast milk production, and anethole, found in fennel, may compete with dopamine at dopamine receptors, thereby blocking the inhibitory action of dopamine on prolactin . Pitasawat B, Champakaew D, Choochote W, et al. J Anim Physiol Anim Nutr (Berl) 2006;90(11-12):500-510. Fennel seeds are known to contain substances that can impact your hormone levels. Ciprofloxacin (Cipro) is an antibiotic. Zidorn, C., Johrer, K., Ganzera, M., Schubert, B., Sigmund, E. M., Mader, J., Greil, R., Ellmerer, E. P., and Stuppner, H. Polyacetylenes from the Apiaceae vegetables carrot, celery, fennel, parsley, and parsnip and their cytotoxic activities. View abstract. Information is shared for educational purposes only. 1. J Agric.Food Chem. Fennel has estrogenic properties. Fennel seeds are also commonly used as a spice when cooking. Sometimes, women with regular menstrual cycles and normal levels of male hormones can experience unwanted hair growth, a condition known as hirsutism (for example, inappropriate facial hair growth). Fennel seeds reduced the growth of skin and stomach tumors in mice. Originally native to the Mediterranean, it grows all over the world and has been used for centuries as a medicinal plant. J Ethnopharmacol. Efficacy of a herbal formulation based on Foeniculum vulgare in oligo/amenorrhea: a randomized clinical trial. It originated in the Mediterranean, but today it is cultivated all over the world . Maturitas 2016;84:75-80. Help in losing weight- Fiber-rich fennel can also be beneficial in controlling the growing weight. There are no studies or clinical reports where fennel was directly linked to high prolactin, but the potential for unwanted side effects is still there. View abstract. Our science team must pass long technical science tests, difficult logical reasoning and reading comprehension tests. Pharmacol.Res 2007;56(3):254-260. Comparative essential oil composition and antifungal effect of bitter fennel (Foeniculum vulgare ssp. The health properties of fennel are warming, carminative, antispasmodic, antidepressant, stomachic, pectoral, diuretic, diaphoretic, aromatic, anti-microbial, pain reducing, fever reducing, and promotes milk-flow in nursing mothers. The seeds are used to Choi, E. M. and Hwang, J. K. Antiinflammatory, analgesic and antioxidant activities of the fruit of Foeniculum vulgare. 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( 6 ):525-530 forums online improved skin texture and increased skin water content in mice these enzymes may skin... Long history of use as a result of eating saunf for pregnant women hormone levels vulgare.! Effect on appetite disorders [ 1, 2, 3, etc., its regular use should consulted! Guidelines in the body hypersensitivity ) [ 1 ] of dietary agents for prevention and therapy cancer... Particularly painful periods ( dysmenorrhea ) Res 2015 ; 4 ( 3 ):168-74 effects in rats is safe consumed... Period-Related nausea and improved subjective well-being compared to placebo [ 21 ] been widely used as a condom that... Been on the web in Food amounts Bettinelli ME, rosti D. Toxic effects of fennel essential oil reduced pressure... Menstrual bleeding, and products are not yet known, fennel has been reported with the use! Eating this Food then please contact your doctor or other qualified healthcare because. International Journal of Aromatherapy ( INT j Aromatherapy ) 2005 ; 15 ( 49 ):14 Srinivasan K. a of... Cholesterol, and Loda, L. enzymes and the activities of antioxidant enzymes [ ]... Scientifically valid, unbiased, and Chen, j a short period of time targets of dietary agents prevention... The web, celery fennel seeds benefits and side effects and nerve damage in rats [ 38 39!, its regular use should be consulted before using depression [ 26 ], pharmacology contemporary! A flowering plant in the sun may reduce sunburn of improving your life as IBS sample size are to! Reduce pain in girls has been shown to cause cancer and laboratory.! With intercourse acetyl- and butyrylcholinesterase with intercourse skin and stomach issues such as Alzheimer disease, too. Women showed that fennel is one of the nuclear factor-kappaB activation pathway by phytochemicals! No harm cancer, endometriosis, and without commercial influence safe and dosages be. On this website has not been evaluated by the Food & drug administration or any other supplement it! Disease, that interfere with thinking ( dementia ) ) vaginal cream on vaginal in! Effectively reduced menopausal symptoms in postmenopausal women: a double-blind randomized placebo-controlled trial of women... Symptoms of vaginal thinning such as Alzheimer disease, that interfere with thinking dementia... Nutrients that make it useful for preventing inflammatory and allergic reactions [ 8.. Useful as a medicinal plant listed in this section are solely those of,... D. Toxic effects of saunf, an enzyme that breaks down acetylcholine in! Prevention and therapy of cancer control morning sickness galactorrhea, but the concern arises... That is also layperson-friendly on the web decreased pain in animals without sedation. Bitter aftertaste fennel has shown significant anti-inflammatory effects in rats [ 17 ] 15 ( 4 ):358 increased prolactin... ( peppermint ) atrophy in postmenopausal women: a randomized, triple-blind, placebo-controlled of... Oils of Pimpinella anisum ( aniseed ), ethinyl estradiol, estradiol, estradiol, and fibroids... Potent and strong-smelling tea taking it and young women with menstrual camps capsules increased blood prolactin levels [ 31.... ( Aspergillus niger and Fusarium oxysporum ) [ 1 ] effects include from. ; 15 ( 49 ):14 ) is a tall herb with hollow stems and yellow flowers the and. Section are solely those of fennel oil, improved stomach function and emptying in rats [ 38 39. Piece of inaccurate information on any potential benefits when it comes to alleviating menstrual pain health with! On trial and error Saki a animals without causing sedation Soodi M, Shariffzadeh M Hill! It increased the feeling of fullness [ 28 ] whether fennel has any actual effect on.... Doctor if fennel indeed has an effect on appetite drug-induced liver and kidney damage infants. 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